Postdoctoral Fellow - Cheminformatics New Approach Methodologies for Impurities

ROLE SUMMARY
We are excited to announce a postdoctoral fellow opportunity to join Pfizer's Drug Safety Research and Development group at the Groton, CT site.
This role will develop and apply computational chemistry and toxicology methods for assessing small molecule impurities to identify and quantify risks. They will use read-across, chemical feature selection, and ML/AI methods to develop frameworks and provide methods for evaluating structures.
Progress in this space will be driven by sound scientific arguments expressed through external publications, presentations, and software releases. This role will interact with a diverse team both internal and external with the goal of influencing both internal and external processes for impurity risk management. An ideal candidate will have a strong background in chemistry, cheminformatics, and an interest in interacting with regulatory processes.
ROLE RESPONSIBILITIES

• Develop, validate, and apply new approach methods for impurities
• Implement python and/or R workflows to assess impurities and communicate actions including APIs and web apps
• Collaborate with toxicologists, data scientists, and informatics teams to integrate in-silico, in-vitro, and in-vivo results into frameworks
• Communicate findings through reports, presentations, publications, and software packages both internally and externally to influence key stakeholders and regulatory processes

BASIC QUALIFICATIONS

• Ph.D. in Computational Chemistry/Toxicology or related field
• Willingness to make a minimum 2-year commitment (fixed-term position)
• No more than 2 years of post-degree experience
• Successful record of scientific publications with at least one first-author manuscript published or submitted for publication in a peer-reviewed journal
• Expertise in Python and/or R for data analysis
• Domain knowledge in small molecules and interactions with biological systems

PREFERRED QUALIFICATIONS

• Proficiency with cheminformatics toolkits (e.g. rdkit, openeye)
• Experience with read across and chemical similarity methods
• Understanding of regulatory frameworks for impurities

PHYSICAL/MENTAL REQUIREMENTS
Ability to perform mathematical calculations and ability to perform complex data analysis
Additional Information
Relocation support available
Work Location Assignment: Hybrid
The annual base salary for this position ranges from $62,700.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development